The ubiquitylation and deubiquitylation of key molecules involved in the regulation of a cell's response to DNA damage has become an important area of research for therapy of cancers. We focus on ubiquitylation / deubiquitylation pathways related to the DNA replication apparatus and in the dysregulation of DNA damage response induced by viral oncoproteins.

Short and long noncoding RNAs are turning out to be very important for various facets of biology. We study them in the context of how they regulate differentiation of skeletal muscle and the progression of prostate cancer.

With the revolution of genomic sequencing, questions relating to where origins of replication are located, what genes are important for cancer progression or for prediction of responsiveness to chemotherapy, and whether there are new forms of nucleic acid molecules in the cell or in our body fluids have become easier to access. We take a leading role in these areas of exploration.
Anindya Dutta - About Dr. Dutta

Dr. Dutta obtained his medical degree from Christian Medical College, Vellore, India, and his PhD from Rockefeller University with Dr. H. Hanafusa and did his postdoctoral work with Dr. Bruce Stillman at Cold Spring Harbor Laboratory. After a short residency in Anatomic Pathology at Brigham and Women's Hospital, he joined the faculty as Asst. and Assoc. Professor of Pathology. In 2003 he was recruited to UVA as the Harry Byrd Professor of Biochemistry and Molecular Genetics and Professor of Pathology. He is currently the Harrison Distinguished Professor and Chair of the Dept. of Biochemistry and Molecular Genetics.

Dr. Dutta's research interests cover genomic instability in cancer cells and noncoding RNAs in differentiation and cancer. His laboratory identified defined the cyclin-binding Cy motifs on CDK inhibitors and substrates, many of the replication initiation proteins in human cells, used genomics technology to identify hundreds of origins of replication in human chromosomes, discovered the roles of geminin and Emi1 in cells preventing over-replication of cellular DNA, and identified a novel class of circular DNA present in normal mammalian cells. His laboratory has also discovered many microRNAs that inhibit cell proliferation and promote differentiation during the conversion of muscle stem cells to mature muscle and microRNAs that contribute to the phenotypes of advanced prostate cancer. In the last decade the laboratory has focused on a novel family of short RNAs discovered in the lab, tRFs, and on several long noncoding RNAs critical for cancer progression. He has trained over thirty scientists who continue research in academia or industry, and has received the following honors: Elected Fellow of the AAAS, Ranbaxy Award for studies on genome instability, the Outstanding Investigator Award of the American Society for Investigative Pathology and the Distinguished Scientist Award from the University of Virginia.
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Latest News
Nov 2018: Congratulations to Dr. Zhangli Su, Dr. Anindya Dutta and Dr. John Lukens for receiving the UVA Supporting Transformative Autism Research (STAR) Pilot Award to work on microRNAs in autism.

Oct 2018: Congratulations to Dr. Manjari Kiran for getting her paper accepted in Molecular Neurobiology.

Sep 2018: Congratulations to Dr. Shashi Kiran on getting his paper accepted in Molecular Cell.

Aug 2018: Dr. Dutta just returned from chairing a Gordon Conference on Genome Stability in Hong Kong.

Aug 2018: Teressa Paulsen gave a very well-received talk at Gordon Conference on Genome Stability in Hong Kong.

July 2018: Dr. Bruno Karia successfully defended Ph.D. thesis. Congratulations!

April 2018: Congratulations to Dr. Ji-Hye Ahn on receiving a Postdoctoral Fellowship from the National Research Foundation of Korea.

April 2018: Congratulations to Dr. Takaaki Tsunematsu on receiving a Postdoctoral Fellowship from the Japan Society for Promotion of Science.

April 2018: Congratulations to Roza Przanowska for receiving a Predoctoral Fellowship from the American Heart Association.